TRANSLATIONAL PHYSIOLOGY Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier
نویسندگان
چکیده
Jurgen Karczewski,* Freddy J. Troost,* Irene Konings, Jan Dekker, Michiel Kleerebezem, Robert-Jan M. Brummer, and Jerry M. Wells TI Food & Nutrition, Nieuwe Kanaal, Wageningen; Host-Microbe Interactomics Group, Animal Sciences, University of Wageningen; Department of Internal Medicine, Division of Gastroenterology & Hepatology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht; NIZO Food Research, Ede; Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands; School of Health and Medical Sciences, Örebro University, Örebro, Sweden
منابع مشابه
Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier.
Lactobacillus plantarum, a commensal bacterium of humans, has been proposed to enhance the intestinal barrier, which is compromised in a number of intestinal disorders. To study the effect of L. plantarum strain WCFS1 on human barrier function, healthy subjects were administered L. plantarum or placebo in the duodenum for 6 h by means of a feeding catheter. The scaffold protein zonula occludens...
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BACKGROUND Previous studies indicated that the micro integral membrane protein located within the media place of the integral membrane protein of Lactobacillus plantarum CGMCC 1258 had protective effects against the intestinal epithelial injury. In our study, we mean to establish micro integral membrane protein -knockout Lactobacillus plantarum (LPKM) to investigate the change of its protective...
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Necrotizing enterocolitis (NEC) is a serious intestinal disease that occurs in newborn infants. It is associated with major morbidity and affects 5% of all infants admitted to neonatal intensive care units. Probiotics have variable efficacy in preventing necrotizing enterocolitis. Tight junctions (TJ) are protein complexes that maintain epithelial barrier integrity. We hypothesized that the pro...
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Purpose: This study designed to examine polarized culture of epithelial cells from human ovidutc and their ultrastracture under polarizing condition. Materials and Methods: The human oviduct was obtained from patients having undergone total hysterectomy and epithelial cells were isolated using collagenase type I. The epithelial cells were either cultured on ECM (Extracellular matrix) Gel coate...
متن کاملTRANSLATIONAL PHYSIOLOGY Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability
Dokladny, Karol, Pope L. Moseley, and Thomas Y. Ma. Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability. Am J Physiol Gastrointest Liver Physiol 290: G204–G212, 2006; doi:10.1152/ajpgi.00401.2005.— The effects of physiologically relevant increase in temperature (37– 41°C) on intestinal epithelial tight junction (TJ) barrier ha...
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